研究方向

环境生物学、昆虫分子遗传学

主要从事环境生物学，昆虫分子遗传学的研究。以昆虫基因组信息为基础，以基因组编辑和遗传转化技术为平台在黑水虻资源化利用有机废弃物、昆虫性别决定机理、昆虫种群的遗传调控和等领域开展基础与应用基础研究。2008年获得国家杰出青年基金，第十四届全国人大代表。

个人简历

2023.3-至今：韦德体育官网首页 特聘教授

2001－2023：中国科学院上海植物生理生态研究所研究员，课题组长

1998－2001：日本IKARI环境事业集团主任研究员

1995－1998: 日本东京大学博士后（日本学术振兴学会资助）

1993－1995：中南林业科技大学副教授

1987－1990：中南林业科技大学讲师

1990-1993：中国科学院上海昆虫研究所，博士研究生，1993年获得博士学位

1984-1987：中南林业科技大学，研究生，1987年获得硕士学位

1980-1984：西北农林科技大学，本科，1984年获得学士学位

代表性论著

Xu Yang, Dongbin Chen, Shirui Zheng, Meiyan Yi, Shanshan Wang,Yongjian Liu, Lianyan Jing, Zulian Liu, Dehong Yang, Yujia Liu,Linmeng Tang, James R. Walters, Yongping Huang*. The Prmt5-Vasa module is essential for spermatogenesis in Bombyx mori. Plos Genetics. 2023.

Lansa Qian, Xu Yang, Xiaomiao Xu, Dehong Yang, Chenxu Zhu, Meiyan Yi,Honglun Bi, Yaohui Wang, Yongping Huang*. SPSL1 is essential for spermatophore formation and sperm activation in Spodoptera frugiperda. Plos Genetics. 2023.

Lansa Qian, Xia Xu, Meiyan Yi, Honglun Bi, Xiaowei Li, Xiaomiao Xu, Zulian Liu, Gangqi Fang, Yongcheng Dong, Yongping Huang,*, and Yaohui Wang,* Intersex regulates larval growth and wing development in Agrotis ipsilon. Entomologia Generalis. 2023.

Xingyu Luo, Gangqi Fang, Kuangqin Chen, Yu Song, Tianyi Lu, Jeffery K. Tomberlin, Shuai Zhan, Yongping Huang*. A gut commensal bacterium promotes black soldier fly larval growth and development partly via modulation of intestinal protein metabolism. mBio. 2023.

Bihui Chen, Zongqing Kou, Yuguo Jiang, Xingyu Luo, Peili Li, Kaiji Sun, Weiwei Wang, Yongping Huang, Yaohui Wang. Intersex is required for female sexual development in Hermetia illucens. Insect Science. 2023.

Yongcheng Dong*, Xiaomiao Xu*, Lansa Qian, Zongqing Kou, Awawing A Andongma, Lijun Zhou, Yongping Huang, Yaohui Wang. Genome-wide identification of yellow gene family in Hermetia illucens and functional analysis of yellow-y by CRISPR/Cas9. Insect Science. 2023.

Dongbin Chen, Xu Yang, Dehong Yang, Yujia Liu, Yaohui Wang, Xingyu Luo, Linmeng Tang, Meiyan Yi, Yongping Huang, Yanqun Liu, Zulian Liu. The RNase III enzyme Dicer1 is essential for larval development in Bombyx mori. Insect Science. 2023.

Zongqing Kou, Xingyu Luo, Yuguo Jiang, Bihui Chen, Yu Song, Yaohui Wang, Jun Xu, Jeffery K Tomberlin, Yongping Huang. Establishment of highly efficient transgenic system for black soldier fly (Hermetia illucens). Insect Science. 2023.

Linmeng Tang, Dehong Yang, Zhiwei Liu, Yaohui Wang, Xu Yang, Yujia Liu, Dongbin Chen, Zheng Tang, Yongping Huang*. Functional characterization of Bmcap in uric acid metabolism in the silkworm. Insect Science. 2023.

Zhi Dong, Guiyun Li, Kaixiang Zhang, Zongqing Kou, Yixiang Zhang, Shuai Zhan, Yongping Huang, Gangqi Fang. BSFbase: The comprehensive genomic resource for a natural recycler, the black soldier fly (Hermetia illucens L.). Insect Science.

Luo X, Qian Y, Lin Y, Tang Z, Jeffery T, Liu W*, Huang YP*. 2022. Black soldier fly larvae effectively degrade lincomycin from pharmaceutical industry. Journal Environmental Management. 307 (2022) 114539

Jiang Y, Ma J, Wei Y, Liu Y, Zhou Z, Huang YP*, Wang PP*, Yan X*. 2022. De novo biosynthesis of sex pheromone components of Helicoverpa armigera through an artificial pathway in yeast. Green Chemistry. 24, 767–778

Yang D, Xu J, Chen K, Liu Y, Yang X, Tang L, Luo X, Liu Z, Li M, Walters J *, Huang YP*. 2022. BmPMFBP1 regulates the development of eupyrene sperm in the silkworm, Bombyx mori. PLOS Genetics https://doi.org/10.1371/journal.pgen.1010131

Liu Y, Chen D, Zhang X, Chen S, Yang D, Tang L, Yang X, Wang Y, Luo X, Wang M, Hu ZH*, and Huang YP*. 2022. Construction of baculovirus-inducible CRISPR-Cas9 antiviral system targeting BmNPV in Bombyx mori. Viruses. （accepted）

Xu X, Wang YH, Liu ZL, Wang YQ, He L, Li K, Huang YP*. 2021. Disruption of egg-specific protein causes female sterility in Bombyx mori. Insect Science. doi: 10.1111/1744-7917.12904. Epub ahead of print. PMID: 33629486.

Yang X, Chen K, Wang Y, Yang D, Huang YP*. 2021. The Sex Determination Cascade in the Silkworm. Genes (Basel). 12(2):315. doi: 10.3390/genes12020315.

Wang Y, Xu X, Chen X, Li X, Bi H, Xu J, Zhu C, Niu C, Huang YP*. 2021. Mutation of P-element somatic inhibitor induces male sterility in the diamondback moth, Plutella xylostella. Pest Management Science. 77(7):3588-3596. doi: 10.1002/ps.6413.

Yang X, Zhang X, Liu Y, Yang D, Liu Z, Chen K, Tang L, Wang M, Hu Z, Zhang S, Huang YP*. 2021. Transgenic genome editing-derived antiviral therapy to nucleopolyhedrovirus infection in the industrial strain of the silkworm. Insect Biochemistry and Molecular Biology. 139:103672. doi: 10.1016/j.ibmb.2021.103672.

Tang L, Yang D, Wang Y, Yang X, Chen K, Luo X, Xu J, Liu Y, Tang Z, Zhang Q, Liu Z, Huang YP*. 2021. 5'-Nucleotidase Plays a Key Role in Uric Acid Metabolism of Bombyx mori. Cells.10(9):2243. doi: 10.3390/cells10092243.

Wang Y, Fang G, Chen X, Cao Y, Wu N, Cui Q, Zhu C, Qian L, Huang YP*, Zhan S*. 2021. The genome of the black cutworm Agrotis ipsilon. Insect Biochem Mol Biol. 139:103665. doi: 10.1016/j.ibmb.2021.103665.

Zhang X, Yang D, Yang X, Zhang X, Zhang Y, Huang Y, Zhang S, Liu Z*. 2021. U1 small nuclear ribonucleoprotein is essential for early larval development in silkworm, Bombyx mori. Insect Sci. doi: 10.1111/1744-7917.12946. Epub ahead of print. PMID: 34231971.

Fang G, Zhang Q, Chen X, Cao Y, Wang Y, Qi M, Wu N, Qian L, Zhu C, Huang YP*, Zhan S*. 2021. The draft genome of the Asian corn borer yields insights into ecological adaptation of a devastating maize pest. Insect Biochemistry and Molecular Biology 138:103638. doi: 10.1016/j.ibmb.2021.103638. Epub 2021 Aug 21. PMID: 34428581.

Chen K, Yu Y, Yang D, Yang X, Tang L, Liu Y, Luo X, R Walter J, Liu Z, Xu J, Huang YP*. 2020. Gtsf1 is essential for proper female sex determination and transposon silencing in the silkworm, Bombyx mori. PLoS Genet. 16(11):e1009194. doi: 10.1371/journal.pgen.1009194.

Xu J, Liu W, Yang D, Chen S, Chen K, Liu Z, Yang X, Meng J, Zhu G, Dong S, Zhang Y, Zhan S, Wang G, Huang YP*. 2020. Regulation of olfactory-based sex behaviors in the silkworm by genes in the sex-determination cascade. PLoS Genet. 16(6):e1008622. doi: 10.1371/journal.pgen.1008622.

Liu Z, Xu J, Ling L, Luo X, Yang D, Yang X, Zhang X, Huang YP*. 2020. miR-34 regulates larval growth and wing morphogenesis by directly modulating ecdysone signalling and cuticle protein in Bombyx mori. RNA Biol. 17(9):1342-1351. doi: 10.1080/15476286.2020.1767953.

Xu J, Luo X, Fang G, Zhan S, Wu J, Wang D, Huang YP*. 2020. Transgenic expression of antimicrobial peptides from black soldier fly enhance resistance against entomopathogenic bacteria in the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology 27:103487. doi: 10.1016/j.ibmb.2020.103487.

Xu X, Wang Y, Bi H, Xu J, Liu Z, Niu C, He L, James AA, Li K, Huang YP*. 2020. Mutation of the seminal protease gene, serine protease 2, results in male sterility in diverse lepidopterans. Insect Biochemistry and Molecular Biology 116:103243. doi: 10.1016/j.ibmb.2019.103243. Epub 2019 Sep 18.

Zhang R, Zhang Z, Huang YP, Qian A, Tan A. 2020. A single ortholog of teashirt and tiptop regulates larval pigmentation and adult appendage patterning in Bombyx mori. Insect Biochemistry and Molecular Biology 121:103369. doi: 10.1016/j.ibmb.2020.103369.

Zhang S, Shen S, Peng J, Zhou X, Kong X, Ren P, Liu F, Han L, Zhan S, Huang YP, Zhang A, Zhang Z. 2020. Chromosome-level genome assembly of an important pine defoliator, Dendrolimus punctatus (Lepidoptera; Lasiocampidae). Molecular Ecology Resources. 20(4):1023-1037. doi: 10.1111/1755-0998.13169.

Chen S, Liu Y, Yang X, Liu Z, Luo X, Xu J, Huang YP*. 2020. Dysfunction of dimorphic sperm impairs male fertility in the silkworm. Cell Discovery. 6:60. doi: 10.1038/s41421-020-00194-6.

Liu ZL, Xu J, Ling L, Yang DH, Chen SQ, Huang YP*. 2020. MicroRNA-2738 regulates gene expression in the sex determination pathway in Bombyx mori. Insect Science. 27(4):646-654. doi: 10.1111/1744-7917.12694.

Li X, Liu Q, Liu H, Bi H, Wang Y, Chen X, Wu N, Xu J, Zhang Z, Huang YP*, Chen H. 2020. Mutation of doublesex in Hyphantria cunea results in sex-specific sterility. Pest Management Science. 76(5):1673-1682. doi: 10.1002/ps.5687.

Xu X, Bi H, Wang Y, Li X, Xu J, Liu Z, He L, Li K, Huang YP*. 2020. Disruption of the ovarian serine protease (Osp) gene causes female sterility in Bombyx mori and Spodoptera litura. Pest Management Science. 76(4):1245-1255. doi: 10.1002/ps.5634.

Wang Y, Gao B, Zhang G, Qi X, Cao S, Akami M, Huang YP, Niu C. 2020. Mutation of Bdpaired induces embryo lethality in the oriental fruit fly, Bactrocera dorsalis. Pest Management Science. 76(3):944-951. doi: 10.1002/ps.5602.

Zhan S., Fang G.Q, Cai M.M., Kou Z.Q., Xu J., Cao Y.H., Bai L., Zhang Y.X., Jiang Y.M., Luo X.Y., Xu J., Xu X., Zheng L.Y., Yu Z.N., Yang H., Zhang Z.J., Wang S.B, Tomberlin J.K., Zhang J.B., Huang Y.P.. 2020. Genomic landscape and genetic manipulation of the black soldier fly Hermetia illucens, a natural waste recycler. Cell Research. 30(1):50-60.

Xu X., Wang Y.H., Bi H.L., Xu J., Liu Z.L., Niu C.Y., He L., James A.A., Li K., Huang Y.P. 2019. Mutation of the seminal protease gene, serine protease 2, results in male sterility in diverse lepidopterans. Insect Biochemistry and Molecular Biology. 116: 103243.

Xu J., Xu X., Zhan S., Huang Y.P*. 2019. Genome editing in insects: Current status and challenges. National Science Review, nwz008,  https://doi.org/10.1093/ nsr/nwz008 Published: 05 February 2019.

Chen K., Chen S.Q., Xu J., Yu Y., Liu Z.L., Tan A.J., Huang Y.P.* 2019. Maelstrom regulates spermatogenesis of the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology. 109:43-51.

Wu N.N., Zhang S.F., Li X.W., Liu X.J., Wang Q.H., Liu Q., Liu H.H., Hu X., Zhou J.X.G., James A.A., Zhang Z., Huang Y.P*., Zhan S*. 2019. Fall webworm genomes yield insights into rapid adaptation of invasive species. Nature Ecology & Evolution 3:105–115. Li X.W., Liu Q., Liu H.H., Bi, H.L., Wang Y.H., Chen X.E., Wu N.N., Xu J., Zhang Z., Huang Y.P. *, Chen H.*  Mutation of doublesex in Hyphentria cunea results in sex-specific sterility. Pest Management Sciences.  doi: 10.1002/ps.5687. [Epub ahead of print].

Du Q., Wen L., Zheng S.C., Bi H.L., Huang Y.P., Feng Q.L., Liu L. 2019. Identification and functional characterization of doublesex gene in the testis of Spodoptera litura. Insect Science. 26(6):1000-1010.

Chen X.E., Cao Y.H., Zhan S., Tan A.J., Palli S.R., and Huang Y.P. 2019. Disruption of sex-specific doublesex exons results in male- and female-specific defects in the black cutworm, Agrotis ipsilon. Pest Management Sciences. 75: 1697–1706.

Bi H.L., Xu J., He L., Zhang Y., Li K., Huang Y.P. 2019. CRISPR/Cas9-mediated ebony knockout results in puparium melanism in Spodoptera litura. Insect Sciences. 2019 Jan 27. doi: 10.1111/1744-7917.12663.

Liu N., Li H.J., Chevrette M.G., Zhang L., Cao L., Zhou H.K., Zhou X.G., Zhou Z.H., Pope P.B., Currie C.R., Huang Y.P., Wang Q. 2018. Functional metagenomics reveals abundant polysaccharide-degrading gene clusters and cellobiose utilization pathways within gut microbiota of a wood-feeding higher termite. The ISME Journal. doi: 10.1038/s41396-018-0255-1.

Xu J., Chen R.M., Chen S.Q., Chen K., Tang L.M., Yang D.H., Yang X., Zhang Y., Song H.S., Huang Y.P. 2018. Identification of a germline-expression promoter for genome editing in Bombyx mori. Insect Sci. 2018 Dec 14. doi: 10.1111/1744-7917.12657. [Epub ahead of print].

Wang Y.H., Chen X.E., Yang Y., Xu J. Fang G.Q., Niu C.Y., Huang Y.P., Zhan S. 2018. The Masc gene product controls masculinization in the black cutworm, Agrotis ipsilon. Insect Sci. 2018 Aug 8. doi: 10.1111/1744-7917.12635. [Epub ahead of print].

Liu Z.L., Xu J., Ling L., Zhang R., Shang P., Huang Y.P. CRISPR disruption of TCTP gene impaired normal development in the silkworm Bombyx mori. Insect Sci. 2018 Jan 9. doi: 10.1111/1744-7917.12567. [Epub ahead of print]

Liu Z.L., Ling L., Xu J., Zeng B., Huang Y.P. Shang P., Tan A.J. 2018. MicroRNA-14 regulates larval development time in Bombyx mori. Insect Biochem Mol Biol.  93:57-65.

Xu X., Bi H.L., Zhang Z.J., Yang Y., Li K., Huang Y.P., Zhang Y., He L.. 2018. BmHpo mutation induces smaller body size and late stage larval lethality in the silkworm, Bombyx mori. Insect Sci. 2018 Dec; 25(6):1006-1016. doi: 10.1111/1744-7917.12607. Epub 2018 Jul 24.

Zhang Z.J., Niu B.L., Ji D.F., Li M.W., Li, K., James A.J., Tan A.J., Huang Y.P. 2018. Silkworm genetic sexing through W chromosome linked, targeted gene integration. Proceedings of the National Academy of Sciences, USA 115 (35):8752-8756.

Xu J., Dong Q.L., Yu Y., Niu B.L., Ji D.F., Li M.W., Huang Y.P., Chen X., Tan A.J. 2018. Mass spider silk production through targeted gene replacement in Bombyx mori. Proceedings of the National Academy of Sciences, USA 115 (35):8757-8762.

Chen X.E., Cao Y.H., Zhan S., Zhang Y., Tan A.J., Huang Y.P. 2018. Identification of yellow gene family in Agrotis ipsilon and functional analysis of Aiyellow-y by CRISPR/Cas9. Insect Biochemistry and Molecular Biology 94:1-9.

Li Z.Q., You L., Yan D., James A.A., Huang Y.P., Tan A.J. 2018. Bombyx mori histone methyltransferase BmAsh2 is essential for silkworm piRNA-mediated sex determination. PLoS Genetics. doi.org/10.1371/journal.pgen.1007245.

Cai M., Ma S., Hu R., Tomberlin J.K., Yu C., Huang Y.P., Zhan S., Li W., Zheng L., Yu Z., Zhang J. 2018. Systematic characterization and proposed pathway of tetracycline degradation in solid waste treatment by Hermetia illucens with intestinal microbiota. Environmental Pollution. https://doi.org/10.1016/j.envpol.2018.06.105

Chen S.Q., Hou C.X., Bi H.L., Wang Y.Q., Xu J., Li M.W., James A., Huang Y.P., Tan A.J. 2017. Transgenic CRISPR/Cas9-mediated viral gene targeting for antiviral therapy of Bombyx mori nucleopolyhedrovirus (BmNPV). Journal of Virology. doi: 10.1128/JVI.02465-16.

Xu J., Chen S.Q., Zeng B.S., James A., Tan A.J., Huang Y.P. 2017. Bombyx mori P-element Somatic Inhibitor (BmPSI) is a key auxiliary factor for silkworm male sex determination. PLoS Genetics. 13(1): e1006576. doi: 10.1371/ journal. pgen. 1006576.

Xu J., Zhan S., Chen S.Q., Zeng B.S., Li Z.Q., James A.A., Tan A.J., Huang Y.P. 2017. Sexually dimorphic traits in the silkworm, Bombyx mori, are regulated by doublesex. Insect Biochemistry and Molecular Biology 80:42-51.

Liu H.H., Liu Q., Zhou X.G., Huang Y.P., Zhang Z. 2017. Genome Editing of Wnt-1, a gene associated with segmentation, via CRISPR/Cas9 in the pine caterpillar moth, Dendrolimus punctatus. Front Physiol. 7:666. doi: 10.3389/fphys.2016. 00666. eCollection 2016.

Liu Q, Liu W., Zeng BS, Wang GR, Hao DJ, Huang Y.P. 2017. Deletion of the Bombyx mori odorant receptor co-receptor (BmOrco) impairs olfactory sensitivity in silkworms. Insect Biochemistry and Molecular Biology 86:58-67.

Zeng B.S., Huang Y.P., Xu, J., Shiotsuki T., Bai H., Palli S.R., Huang Y.P., Tan A.J. 2017. The FOXO transcription factor controls insect growth and development by regulating juvenile hormone degradation in the silkworm, Bombyx mori. Journal of Biological Chemistry. doi: 10.1074/jbc.M117.777797.

Zeng B., Zhan S., Wang Y.Q., Xu J., Huang Y.P., Liu Q., Li Z. Q., Huang Y.P., Tan A.J. 2016. Expansion of CRISPR targeting sites in Bombyx mori. Insect Biochemistry and Molecular Biology 72:31-40.

Huang, Y., Wang, Y., Zeng, B., Liu, Z., Xu, X., Meng, Q., Huang, Y., Yang, G., Vasseur, L., Gurr, G.M., Minsheng, Y., 2017. Functional characterization of Pol III U6 promoters for gene knockdown and knockout in Plutella xylostella. Insect Biochem. Mol. Biol. 89, 71-78.

Huang Y.P., Chen Y.Z., Zeng B. S., Wang Y. J., James A. A., Gurr G. M., Yang G., Lin X. J., Huang Y.P., You M.S. 2016. CRISPR/Cas9 mediated knockout of the abdominal-A homeotic gene in the global pest, diamondback moth (Plutella xylostella). Insect Biochemistry and Molecular Biology 75:98-106.

Zhu G.H., Xu J., Cui Z., Dong X.T., Ye Z.F., Niu D.J., Huang Y.P., Dong S.L. 2016. Functional characterization of SlitPBP3 in Spodoptera litura by CRISPR/Cas9 mediated genome editing. Insect Biochemistry and Molecular Biology 75:1-9.

Bi H. L., Xu J., Tan A.J., Huang Y.P. 2016. CRISPR/Cas9-mediated targeted gene mutagenesis in Spodoptera litura. Insect Science 23(3):469-77.

Zhang Z.J., Aslam A.F., Liu X.J., Li M.W., Huang Y.P., Tan A.J. 2015. Functional analysis of Bombyx Wnt1 during embryogenesis using the CRISPR/Cas9 system. Journal of Insect Physiology 79:73-9.

Li Z.Q., Zeng B.S., Ling L., Xu J., Aslam A.F., Tan A.J., Huang Y.P. 2015. Enhancement of larval RNAi efficiency by over-expressing Argonaute2 gene in the silkworm, Bombyx mori. International Journal of Biological Sciences 11(2):176-185.

Li Z. Q., You L., Zeng B. S., Ling L., Xu J., Chen X., Zhang Z. J., Palli S.R., Huang Y.P., Tan A. J. 2015. Ectopic expression of ecdysone oxidase impairs tissue degeneration in Bombyx mori. Proceedings of the Royal Society B: Biological Sciences 282(1809):20150513. doi: 10.1098/rspb.

Ling L., Ge X., Li Z.Q, Zeng B.S., Xu J., Chen X., Shang P., James A.A., Huang Y.P. Tan A.J. 2015. MiR-2 family targets awd and fng to regulate wing morphogenesis in Bombyx mori. RNA Biology 12(7), 742-748.

Li Z.Q., Jiang J.H., Chen Y.Z., Niu B.L., Meng Z.Q., Huang Y.P., Tan A.J. 2014. PDP1 regulates energy metabolism through food intake and insulin signaling pathway in the red flour beetle, Tribolium castaneum. Archive of Insect Biochemistry and Physiology 85(3): 127-136.

Xu J., Bi H.L., Chen R.M., Aslam A.F., Li Z.Q., Ling L., Zeng B.S., Huang Y.P., Tan A.J. 2015. Transgenic characterization of two testis-specific promoters in the silkworm, Bombyx mori. Insect Molecular Biology. 24(2), 183–190.

Xu J., Wang Y.Q., Li Z.Q., Ling L., Zeng B.S., James A.A., Tan A.J., Huang Y.P. 2014. Transcription activator-like effector nuclease (TALEN)-mediated female-specific sterility in the silkworm, Bombyx mori. Insect Molecular Biology 23(6):800-807.

Xu J., Wang Y.Q., Li Z.Q., Ling L., Zeng B.S., You L., Chen Y.Z., Aslam A.F., Huang Y.P., Tan A.J. 2014. Functional characterization of the vitellogenin promoter in the silkworm, Bombyx mori. Insect Molecular Biology 23(5):550-557.

Wang Y.Q., Li Z.Q., Xu J., Zeng B.S., Ling L., You L., Chen Y.Z., Huang Y.P., Tan A.J. 2013. The CRISPR/Cas system mediates efficient genome engineering in Bombyx mori. Cell Research. 23:1414-1416.

Wang Y.Q., Tan A.J., Xu J., Li Z.Q., Zeng B.S., Ling L., You L., Chen Y.Z., James A.A., Huang Y.P. 2014. Site-specific, TALENs-mediated transformation of Bombyx mori. Insect Biochemistry and Molecular Biology 55:26-30.

Ling L., Ge X., Li Z.Q., Zeng B.S., Xu J., Aslam A.F., Song Q.S., Shang P., Huang Y.P., Tan A.J. 2014. MicroRNA Let-7 regulates molting and metamorphosis in the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology 53:13-21.

Tan A.J., Fu G.L., Jin L., Guo Q.H, You L., Jiang J.H., Li Z.Q., Niu B.L., Meng Z.Q., Morrison N., Alphey L., Huang Y.P. 2013. A transgene-based, female-specific lethality system for genetic sexing of the beneficial insect, Bombyx mori. Proceedings of the National Academy of Sciences, USA 110 (17): 6766–6770.

Ge X., Zhang Y., Jiang J.H., Zhong Y., Yang X.N., Li Z.Q., Huang Y.P., Tan A.J. 2013. Identification of miRNAs in Helicoverpa armigera and Spodoptera litura based on deep sequencing and homology analysis. International Journal of Biological Sciences 9(1):1-15.

Jiang J.H., Ge X., Li Z.Q., Wang Y.Q., Song Q.S., Stanley D.W., Tan A.J., Huang Y.P. 2013. microRNA-281 suppresses ecdysone receptor B isoforms expression in Bombyx mori. Insect Molecular Biology and Biochemistry 43:692-700.

Shao Q.M., Yang B., Xu Q.Y., Li X.Q., Lu Z.Q., Wang C.S., Huang Y.P., Söderhäll K., Ling E.J. 2012. Hindgut innate immunity and regulation of fecal microbiota through melanization in insects. The Journal of Biological Chemistry 287(17): 14270–14279.

Chen A.L., Gao P., Zhao Q.L., Tang S.M., Shen X.J., Zhang G.Z., Qiu Z.Y., Xia D.G., Huang Y.P., Xu Y.M., He N.J. 2013. Mutation of a vitelline membrane protein, BmEP80, is responsible for the silkworm “Ming” lethal egg mutant. Gene 515: 313-319.Hou C.X., Wang X.Y., Li B., Xu A.Y., Huang Y.P., Li M.W. 2013. Mapping and analysis of Bombyx mori. Science of Sericulture 39(1): 35-39.

研究成果

    昆虫是自然界种类最多的动物类群。昆虫正在快速的成为工业生产的新型对象，为国家生产出饲料蛋白、蚕丝蛋白、医药原料、优质油脂和生物有机肥等急需的原料。为解决规模化生产蚕丝蛋白、处理有机废弃物以生产饲料蛋白和媒介传病害虫以及农业病虫害无公害防治等重大问题，我们以昆虫基因组信息为基础，以基因组编辑和遗传转化技术为平台在昆虫性别决定机理、昆虫种群的遗传调控和昆虫与病原微生物互作方面开展基础与应用基础研究。为家蚕规模化生产提供抗病、优良丝质品种，为处理有机废弃物创制高效的黑水虻新品种以及与此配套的规模化生产流程。

荣获奖项

2001年入选“百人计划”

2007年获国务院特殊津贴

2007年获得日本明治乳业生命科学奖杰出奖

2008年获国家杰出青年基金资助